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Global Coalition for Adaptive Research

Our mission is to speed the
discovery and development of
treatments for patients with
rare and deadly diseases.

REMAP-COVID

Info     Latest Results from REMAP

GBM AGILE: Now Enrolling

Info     Press release

INITIAL GOALS

Operationalize GBM AGILE into a self-sustaining
engine of therapeutic and biomarker development
for patients with GBM.
Finance the launch and ongoing activity of new
GBM-focused therapies developed through
GBM AGILE.
Use GBM AGILE as a model for developing an efficient
framework for the discovery and development of
therapies and biomarkers for other rare and deadly diseases.
Randall Garnick Photography, National Brain Tumor Society

LEADERSHIP

The Global Coalition for Adaptive Research (GCAR) is an international partnership


The Global Coalition for Adaptive Research (GCAR) is an international partnership comprised of some of the world’s foremost clinical, translational, and basic science investigators. Through this collaboration and open exchange of ideas, the ultimate beneficiary—the patient—is supported in the fight against rare and deadly diseases.

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GBM AGILE is a seamless Phase II (Efficacy and Safety) / Phase III (Confirmatory) trial to identify effective therapies and the most promising biomarker-defined populations for those therapies in patients with glioblastoma.

GBM AGILE is changing the IDEA of clinical trials

Innovative – Next-generation trial that will lower cost of development and speed progress.

Dynamic – Perpetual learning system to quickly add potentially promising new drugs and drop those that appear to be ineffective.

Efficient – Design and trial structure that will require fewer patients and a shorter time frame to get important answers about a drug's effectiveness.

Accessible – Global effort open to a broad patient population of newly diagnosed and recurrent GBM patients.
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NEWS


Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
FEBRUARY 25, 2021  |  NEJM
Henry Ford Cancer Institute is First in the World to Activate Two New Treatments in GBM AGILE Trial for Glioblastoma
FEBRUARY 3, 2021  |  NEWSWISE
Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system—lessons learned and recommendations
JANUARY 28, 2021  |  BIOMED CENTRAL
Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients
JANUARY 22, 2021  |  NATIONAL INSTITUTES OF HEALTH
Global Coalition for Adaptive Research, Kazia, and Kintara Announce Commencement of Kazia’s Paxalisib and Kintara’s VAL-083 in GBM AGILE Trial
JANUARY 6, 2021  |  BUSINESSWIRE
Global Coalition for Adaptive Research, Amgen, and Eisai Announce First Patient Enrolled in International COVID-19 Trial
OCTOBER 26, 2020  |  BUSINESSWIRE
Kintara and the Global Coalition for Adaptive Research Execute Agreement for VAL-083’s Participation in the GBM AGILE Registrational Study
OCTOBER 21, 2020  |  PRNEWSWIRE
Kazia Executes Agreement to Commence GBM AGILE Pivotal Study
OCTOBER 16, 2020  |  Kazia Therapeutics
Steroids Can Be Lifesaving for Covid-19 Patients, Scientists Report
SEPTEMBER 2, 2020  |  NEW YORK TIMES
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19. The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial
SEPTEMBER 2, 2020  |  JAMA
ALL NEWS

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Copyright © 2021  Global Coalition for Adaptive Research. All Rights Reserved. 617-299-6471
The Global Coalition for Adaptive Research is registered as a 501(c)(3) nonprofit organization. Contributions to the Global Coalition for Adaptive Research are tax-deductible to the extent permitted by law.
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  • Home
  • Leadership
  • About REMAP-COVID
  • GBM AGILE
    • About GBM AGILE
    • GBM AGILE Trial Sites
    • FAQs
    • Strategic Partners
  • News
  • Join Us
  • Contact
  • DONATE