Innovation In Action:
Operationalizing Master Protocols

WHITE PAPER
Published: March 4, 2025

Master Protocols: Transforming Clinical Trials with Innovation and Efficiency

Master protocols, including adaptive platform trials (APTs), are redefining clinical research by enabling the simultaneous evaluation of multiple therapies within a unified framework. While this approach enhances efficiency and accelerates progress, its complexity demands innovative operational strategies. This white paper explores the critical considerations for successfully executing master protocols and APTs, offering insights from leading organizations like the Global Coalition for Adaptive Research (GCAR). Discover key lessons learned and practical solutions to integrate these groundbreaking methodologies into standard practice.

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