Brian M. Alexander

Brian M. Alexander, M.D., M.P.H.

President


Dr. Alexander is a Senior Vice President for Clinical development at Foundation Medicine, Inc. and an Associate Professor of Radiation Oncology at Harvard Medical School and Dana-Farber/Brigham and Women’s Cancer Center. He also founded the Program in Regulatory Science at the Dana-Farber Cancer Institute and is a Member of the Scientific Council of the Harvard/MIT Center for Regulatory Science.

Dr. Alexander received his B.A. from Kalamazoo College, M.D. from the University of Michigan Medical School, and M.P.H. from the Harvard School of Public Health. He completed his training in radiation oncology at the Harvard Radiation Oncology Program.

Dr. Alexander’s research interests focus on innovations in clinical evidence generation to support the development of therapeutics, biomarkers, and novel endpoints. Dr. Alexander co-authored a book entitled “Diagnostic Test Interpretation and Reasoning Under Uncertainty,” detailing the use of Bayesian approaches to clinical decision-making and is the recipient of the Burroughs-Wellcome Innovations in Regulatory Science Award for his work applying such approaches to clinical trial design. Dr. Alexander was the founding principal investigator of INSIGhT, a multi-institutional genomic biomarker-based Bayesian adaptively randomized trial for patients with glioblastoma.

Prior to his faculty appointment at Harvard Medical School, Dr. Alexander served as a White House fellow and Special Assistant to the Secretary of Veterans Affairs. In that role, he helped prepare the VA for the transition of administrations, worked to develop a public reporting system for quality, and served as a health policy advisor to the Secretary. Dr. Alexander organized the standup of the VA’s Coordinating Council on National Health Reform and directed the activities of its multi-team Health Reform Working Group. He was also a member of the Institute of Medicine’s Committee on the Governance and Financing of Graduate Medical Education.