Brian M. Alexander

Brian M. Alexander, M.D., M.P.H.

President, Chief Executive Officer


Dr. Alexander is an associate professor of radiation oncology at Harvard Medical School and the Disease Center leader for Radiation Oncology, Center for Neuro-Oncology, at the Dana-Farber/Brigham and Women’s Cancer Center. He also serves as the head of the Regulatory Science program at the Dana-Farber Cancer Institute and is the deputy director of the Harvard/MIT Center for Regulatory Science.

Dr. Alexander received his B.A. from Kalamazoo College, M.D. from the University of Michigan Medical School, and M.P.H. from the Harvard School of Public Health. He completed his training in radiation oncology at the Harvard Radiation Oncology Program.

Dr. Alexander’s research interests focus on innovations in clinical evidence generation to support the development of therapeutics, biomarkers, and novel endpoints. During his residency, Dr. Alexander co-authored a book entitled “Diagnostic Test Interpretation and Reasoning Under Uncertainty,” detailing the use of Bayesian approaches to clinical decision-making. He is the recipient of the Burroughs-Wellcome Innovations in Regulatory Science Award for his work applying such approaches to clinical trial designs. Dr. Alexander is currently the principal investigator and sponsor of INSIGhT, a multi-institutional genomic biomarker-based Bayesian adaptively randomized trial for patients with glioblastoma. Dr. Alexander’s research also includes evidence generation from patient-derived preclinical models and the statistical modeling and synthesis of therapeutic development data from multiple sources.

Prior to his faculty appointment at Harvard Medical School, Dr. Alexander served as a White House fellow and special assistant to the Secretary of Veterans Affairs. In that role, he helped prepare the VA for the transition of administrations, worked to develop a public reporting system for quality, and served as a health policy advisor to the Secretary. Dr. Alexander organized the standup of the VA’s Coordinating Council on National Health Reform and directed the activities of its multi-team Health Reform Working Group. He was also a member of the Institute of Medicine’s Committee on the Governance and Financing of Graduate Medical Education.